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| 01/01/2004 - 12/31/2008 |
| 2 R01 GM58859 Dinman (PI) |
| The National Institutes of Health |
| The Biochemistry of Programmed Ribosomal Frameshifting. |
| The goals of this project are to characterize the effects of a series of mutations of the translational apparatus on translational fidelity, and on distinct biochemical properties of the ribosome. Specific Aim 1 focuses on 4 ribosomal proteins, Aim 2 focuses on 25S rRNA, and Aim 3 investigates the role of base modification. |
| Role: PI |
| Overlap: none. |
| 07/01/2006 -- 06/30/2011 |
| 1 R01 AI064307 Dinman (PI) |
| The National Institutes of Health |
| Characterization of the SARS-CoV Frameshift Signal. |
|
This study seeks to define the structure and biology of the SARS-CoV frameshift signal. |
| Role: PI |
| Overlap: none. |
| 08/01/2007 - 07/31/2009 |
| MIPS 0701_023 (Dinman) |
| Maryland Industrial Partnerships |
| Pentose fermenting strain of brewers yeast |
|
The goal of this project is to introduce genes from S. degradans into S. cerevisiae in order to produce a strain of yeast capable of fermenting 5 carbon sugars. Aim 1 will establish a strain capable of fermenting xylose, Aim 2 will create a strain able to ferment arabinose, and Aim 3 will optimize a strain able to ferment both pentoses. |
| Role: PI |
| Overlap: none. |
Pending
| 1/01/2008 ? 12/31/2012 |
| 2 R01 GM058859 (Dinman) |
| NIH/NIGMS |
| Translational fidelity in eukaryotes |
|
The goals of this project are to use molecular genetic, biochemical, and structural biological methods to characterize mechanisms of translational fidelity. Specific Aim 1 will characterize the effects of selected mutations on yeast ribosome structure and function, while Aim 2 focuses on the interactions between ribosomes and two mRNA-based translational control elements. |
| Role: PI |
| Overlap: none. |
| 01/01/2008 ? 12/31/2012 |
| 1 R01 GM081721-01 Toth (PI) |
| The National Institutes of Health |
| Biochemical and Biophysical study of the yeast RNA processing helicase Mtr4p. |
|
This study seeks to biochemically characterize Mtr4p and its interactions with Rrp42p and Rrp4p. |
| Role: Paid Collaborator. |
| Overlap: none. |
Completed Research Support(last 3 years)
| 08/01/2003 - 07/31/2005 |
| R21 GM068123 Dinman (PI) |
| National Institutes of Health |
| Regulation of gene expression by ribosomal frameshifting. |
|
The goal of this grant was to identify functional -1 ribosomal frameshift signals in the genome of S. cerevisiae. |
| Role: PI |
| Overlap: none. |
| 08/01/2002 - 7/31/2005 |
| MCB-01-30531 Tumer and Dinman (Co-PIs) |
| The National Science Foundation |
| Pokeweed Antiviral Protein and inhibition of Ribosomal Frameshifting |
|
The goal of this grant was to characterize the effects of PAP resistant mutants of ribosomal protein L3, and to characterize the mechanisms through which PAP inhibited +1 frameshifting in yeast and plants. |
| Role: co-PI |
| Overlap: none. |
| 03/2001/01 - 02/28/2005 |
| R01 GM62143 Dinman (PI) |
| National Institutes of Health. |
| Ribosomal Frameshifting as a Probe of 5S rRNA Function |
|
The goal of this grant was to generate and characterize mutant alleles of 5S rRNA in yeast. |
| Role: PI |
| Overlap: none. |
| 01/01/2002 - 12/31/2005 |
| R03 TW05787 |
| The Fogarty International Center 1 |
| 5S rRNA: topology and function |
|
This grant funded a collaboration between Dr. Dinman and Dr. O. Dontsova, Moscow State University, Moscow Russia for the use of chemical protection methods to identify rRNA structural changes due to mutations in 5S rRNA. |
| Role: PI |
| Overlap: none. |
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